Methyl iodide → N-((S)-6-Bromo-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methyl-5-cyclopropylmethoxy-pyridine-2-carboxamide

HRID 77421

Reaktionsgleichung

Reaktionsgleichung von HRID 77421
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][C@@H:7]([NH2:12])[CH2:6][CH2:5]2.[OH:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]([OH:22])=O)=[N:18][CH:19]=1.Br[CH2:24][CH:25]1[CH2:27][CH2:26]1.[CH3:28]I>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][C@@H:7]([N:12]([CH3:28])[C:20]([C:17]1[CH:16]=[CH:15][C:14]([O:13][CH2:24][CH:25]3[CH2:27][CH2:26]3)=[CH:19][N:18]=1)=[O:22])[CH2:6][CH2:5]2

Komponenten

5

Edukt 4

HCID 6328Methyl iodideHCID 81503BromomethylcyclopropaneHCID 2687405-Hydroxypyridine-2-carboxylic acidHCID 22831536(2S)-6-Bromo-1,2,3,4-tetrahydronaphthalen-2-amine

Produkt 1

HCID 66663511N-((S)-6-Bromo-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methyl-5-cyclopropylmethoxy-pyridine-2-carboxamide

Versuchsvorschrift

According to method G, (S)-6-bromo-1,2,3,4-tetrahydronaphthalen-2-ylamine was coupled with 5-hydroxypyridine-2-carboxylic acid and the product was then alkylated on the phenolic hydroxyl function with bromomethylcyclopropane according to method a Finally, the amide function was alkylated according to method B with methyl iodide. The product was thus obtained with the molecular weight of 415.33 (C21H23BrN2O2); MS (ESI): 415 (M+H+).

Aufarbeitung

  1. customThe product was thus obtained with the molecular weight of 415.33 (C21H23BrN2O2)

Quellen und Nachweise

ORD-Eintrag
ord-88d81b669a224bbfa615843c2afeea02
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08841290B2

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