Benzaldehyde → 4-Methyl-1,7-diphenyl-1,6-heptadiene-3,5-dione

Boric anhydride (0.49 g, 7.0 mmol) was combined with 3-methyl-2,4-pentanedione (5, 1.14 g, 10.0 mmol) and stirred for 24 hr at room temperature under a nitrogen atmosphere. A solution of ethyl acetate (10 ml), benzaldehyde (1b, 2.05 ml, 20.2 mmol) and tributyl borate (11.0 ml, 40.5 mmol) was added and the mixture stirred for 15 min at room temperature. Butylamine (0.20 ml, 2.0 mmol) was added dropwise over 30 min and stirring was continued for 24 hr at room temperature. The resulting mixture was filtered to afford a solid. The crude solid was triturated with methanol to give 1.80 g (62%) of an orange solid: mp 154-157° C. [expected mp 154-157° C.]; 1H NMR: δ 2.17 (s, 3H), 7.12 (d, 2H, J=15.5 Hz), 7.38 (m, 6H), 7.58 (m, 4H), 7.74 (d, 2H, J=15.5 Hz); 13C NMR: δ 12.1, 106.2, 120.8, 182.1, 128.8, 129.9, 135.4, 141.3, 182.4. Anal. Calcd for C20H18O2: C, 82.73; H, 6.25. Found: C, 82.69; H, 6.36.

1. stirringthe mixture stirred for 15 min at room temperature
2. stirringstirring
3. waitwas continued for 24 hr at room temperature
4. filtrationThe resulting mixture was filtered
5. customto afford a solid
6. customThe crude solid was triturated with methanol

ORD-Eintrag

ord-3d438f05a2d9468c92e3939d32888650

Quelldatensatz

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08841326B2