Ammonium Hydroxide → [2-(1-Methyl-pyrrolidin-yl)ethyl] thiourea

HRID 7812

Reaktionsgleichung

Reaktionsgleichung von HRID 7812
[N:1]([CH2:4][CH2:5][CH:6]1[CH2:10][CH2:9][CH2:8][N:7]1[CH3:11])=[C:2]=[S:3].[OH-].[NH4+:13]>>[CH3:11][N:7]1[CH2:8][CH2:9][CH2:10][CH:6]1[CH2:5][CH2:4][NH:1][C:2]([NH2:13])=[S:3]

Komponenten

3

Edukt 2

HCID 14923Ammonium Hydroxide2×HCID 219923282-(2-Isothiocyanatoethyl)-1-methylpyrrolidine

Produkt 1

HCID 21992305[2-(1-Methyl-pyrrolidin-yl)ethyl] thiourea

Versuchsvorschrift

The 2-(2-isothiocyanatoethyl)-1-methylpyrrolidine and concentrated ammonium hydroxide (3 mL) were heated at 100° C. for 30 minutes. Additional ammonium hydroxide (1 mL) was added and heating was continued for an additional 30 minutes. The reaction mixture was allowed to cool to room temperature and then it was lyophilized to give [2-(1-methylpyrrolidin-2-yl)ethyl]thiourea as a very viscous colorless oil.

Aufarbeitung

  1. temperatureheating

Quellen und Nachweise

ORD-Eintrag
ord-6c3f3afcea9a427b9b1ed5038ccd9a33
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087623B2

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