4-Aminophenol → 4-(4-Aminophenoxy)pyridine-2-carboxamide

HRID 78346

Reaktionsgleichung

Reaktionsgleichung von HRID 78346
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([NH2:10])=[O:9])[CH:3]=1.[NH2:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1>CC(N(C)C)=O>[C:8]([C:4]1[CH:3]=[C:2]([O:18][C:15]2[CH:16]=[CH:17][C:12]([NH2:11])=[CH:13][CH:14]=2)[CH:7]=[CH:6][N:5]=1)(=[O:9])[NH2:10]

Komponenten

4

Edukt 2

HCID 4034-AminophenolHCID 3035434-Chloropyridine-2-carboxamide

Produkt 1

HCID 230883384-(4-Aminophenoxy)pyridine-2-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31374DimethylacetamideLösungsmittel

Versuchsvorschrift

Entry 14: 4-Chloropyridine-2-carbonyl chloride HCl salt was reacted with ammonia according to Method A2, Step 3b to form 4-chloro-2-pyridinecarboxamide. 4-Chloro-2-pyridinecarboxamide was reacted with 4-aminophenol according to Method A2, Step 4 using DMAC in place of DMF to give 4-(2-carbamoyl-4-pyridyloxy)aniline. According to Method C4, 2-methoxy-5-(trifluoromethyl)aniline was reacted with phosgene followed by 4-(2-carbamoyl-4-pyridyloxy)aniline to afford the urea.

Quellen und Nachweise

ORD-Eintrag
ord-cf231f4cc8884ff9a82ecbbbc11fd404
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08841330B2

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