Hydrochloric Acid → 2-(2-Methoxyethoxy)benzoic acid

HRID 78405Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 78405
C[O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][CH2:11][CH2:12][O:13][CH3:14].Cl>[OH-].[K+].O>[CH3:14][O:13][CH2:12][CH2:11][O:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[C:3]([OH:15])=[O:2]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 22381872Methyl 2-(2-methoxyethoxy)benzoate

Produkt 1

HCID 134171032-(2-Methoxyethoxy)benzoic acidAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 14797Potassium HydroxideLösungsmittel

Versuchsvorschrift

A mixture of the product of Example 25A (0.27 g, 1.3 mmol) in 40% aqueous potassium hydroxide was stirred for 6 hours. The mixture was then diluted with water, made slightly acidic by the addition of 2 N aqueous HCl, and then extracted three times with ethyl acetate. The combined organic extracts were dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford 0.25 g of the title compound.

Aufarbeitung

  1. extractionextracted three times with ethyl acetate
  2. dry with materialThe combined organic extracts were dried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e3e7113642bb4c3cb746faec7297c14e
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08841334B2

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