2-Amino-4-methylthiazole → Ammonium Hydroxide

HRID 78467Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 78467
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH3:7])[N:6]=1.Br[CH2:9][CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][O:11]1>>[NH4+:1].[OH-:11].[CH3:7][C:5]1[N:6]([CH2:9][CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][O:11]2)[C:2](=[NH:1])[S:3][CH:4]=1

Komponenten

4

Edukt 2

HCID 741432-Amino-4-methylthiazoleHCID 1419172-(Bromomethyl)tetrahydro-2H-pyran

Produkt 2

HCID 14923Ammonium HydroxideHCID 686231274-methyl-3-((tetrahydro-2H-pyran-2-yl)methyl)thiazol-2(3H)-imine

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

A mixture of 2-amino-4-methylthiazole (1.0 g, 8.8 mmol) and 2-(bromomethyl)tetrahydropyran (1.1 mL, 8.8 mmol) was warmed to 85° C. and was allowed to stir for 24 hours. The mixture was cooled to ambient temperature and the crude material was purified via column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2:methanol:NH4OH) to afford the title compound. MS (DCI/NH3) m/z 213 (M+H)+.

Aufarbeitung

  1. temperatureThe mixture was cooled to ambient temperature
  2. customthe crude material was purified via column chromatography (SiO2, 10% methanol in ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-66042b483df64b93849856760d56d233
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08841334B2

Notizen zur Reaktion

Wird geladen…