Water → 1-(2-Isocyanobenzyl)-3-methylurea

HRID 78684Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 78684
Cl.C([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH2:6][NH2:7])#N.[CH3:12][N:13]=[C:14]=[O:15].[CH2:16]([N:18](CC)CC)C.O>ClCCl>[N+:18]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH2:6][NH:7][C:14]([NH:13][CH3:12])=[O:15])#[C-:16]

Komponenten

6

Edukt 4

HCID 962WaterHCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 247216502-(Aminomethyl)benzonitrile hydrochloride

Produkt 1

HCID 580761271-(2-Isocyanobenzyl)-3-methylureaAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

2-cyanobenzylamine hydrochloride (90 g) and Dichloromethane (800 ml) were taken into a round bottomed (RB) flask. Methyl isocyanate (45.6 g) was added at 5° C. Triethylamine (81 g) in Dichloromethane (300 ml) was added at the same temperature and stirred at room temperature for 16 h. Water (1 L) was added and stirred for 30 min. The obtained solid was collected by filtration and dried in oven at 50° C. for 12 h. The yield is 85% and the purity 99.8%.

Aufarbeitung

  1. stirringstirred for 30 min
  2. filtrationThe obtained solid was collected by filtration
  3. customdried in oven at 50° C. for 12 h

Quellen und Nachweise

ORD-Eintrag
ord-d44dadcd95f54f90bf9533bb53ff1bad
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08841447B2

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