Methyl vinyl sulfone → {2-[7-(2-Methanesulfonyl-vinyl)-1H-indol-3-yl)-1,1-dimethyl-ethyl}-carbamic acid tert-butyl ester

HRID 8108

Reaktionsgleichung

Reaktionsgleichung von HRID 8108
[C:1]([O:5][C:6](=[O:29])[NH:7][C:8]([CH3:28])([CH3:27])[CH2:9][C:10]1[C:18]2[C:13](=[C:14](CS(C(F)(F)F)(=O)=O)[CH:15]=[CH:16][CH:17]=2)[NH:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2].[CH:30]([S:32]([CH3:35])(=[O:34])=[O:33])=[CH2:31]>>[C:1]([O:5][C:6](=[O:29])[NH:7][C:8]([CH3:27])([CH3:28])[CH2:9][C:10]1[C:18]2[C:13](=[C:14]([CH:31]=[CH:30][S:32]([CH3:35])(=[O:34])=[O:33])[CH:15]=[CH:16][CH:17]=2)[NH:12][CH:11]=1)([CH3:2])([CH3:4])[CH3:3]

Komponenten

3

Edukt 2

HCID 19354Methyl vinyl sulfoneHCID 69517369[1,1-dimethyl-2-(7-trifluoromethanesulfonyhnethyl-1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester

Produkt 1

HCID 86595247{2-[7-(2-Methanesulfonyl-vinyl)-1H-indol-3-yl)-1,1-dimethyl-ethyl}-carbamic acid tert-butyl ester

Versuchsvorschrift

{2-[7-(2-Methanesulfonyl-vinyl)-1H-indol-3-yl)-1,1-dimethyl-ethyl}-carbamic acid tert-butyl ester is prepared from [1,1-dimethyl-2-(7-trifluoromethanesulfonylmethyl-1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester and methyl vinyl sulfone as described for the preparation of Amine 23 (98%). FDMS m/e=392.2 (M++1).

Quellen und Nachweise

ORD-Eintrag
ord-6bb9173e2bfb4e009592dee1e206c9e3
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087635B2

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