Benzyl 4-methoxy-2-(1-methoxycyclopropyl)pyrrolidine-1-carboxylate → 4-Methoxy-2-(1-methoxycyclopropyl)pyrrolidine

HRID 81136Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 81136
[CH3:1][O:2][CH:3]1[CH2:7][N:6](C(OCC2C=CC=CC=2)=O)[CH:5]([C:18]2([O:21][CH3:22])[CH2:20][CH2:19]2)[CH2:4]1.[H][H]>C(OCC)(=O)C.[Pd]>[CH3:1][O:2][CH:3]1[CH2:7][NH:6][CH:5]([C:18]2([O:21][CH3:22])[CH2:20][CH2:19]2)[CH2:4]1

Komponenten

5

Edukt 2

HCID 86724494Benzyl 4-methoxy-2-(1-methoxycyclopropyl)pyrrolidine-1-carboxylateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 867244954-Methoxy-2-(1-methoxycyclopropyl)pyrrolidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To benzyl 4-methoxy-2-(1-methoxycyclopropyl)pyrrolidine-1-carboxylate (141 mg, 0.462 mmol) dissolved in ethyl acetate (3.1 mL) was added palladium on carbon (49.1 mg, 0.05 mmol). Hydrogen gas was added via balloon and the reaction was stirred at room temperature for 3 hours. The mixture was filtered over celite and concentrated under reduced pressure to afford 4-methoxy-2-(1-methoxycyclopropyl)pyrrolidine.

Aufarbeitung

  1. filtrationThe mixture was filtered over celite and
  2. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-42d9d219fb804727a47f3f298fb60684
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846657B2

Notizen zur Reaktion

Wird geladen…