Water → HCID 178461233, Verbindung

HRID 81275Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 81275
Cl[C:2]1[C:7]2[N:8]([CH2:20][C@H:21]3[CH2:26][CH2:25][C@H:24]([CH3:27])[CH2:23][CH2:22]3)[C:9]([N:11]3[CH2:16][CH2:15][O:14][C@@H:13]4[CH2:17][CH2:18][CH2:19][C@@H:12]34)=[N:10][C:6]=2[CH:5]=[C:4]([Cl:28])[N:3]=1.[CH2:29]([O:36][C:37]1[C:42](B(O)O)=[CH:41][C:40]([Cl:46])=[CH:39][N:38]=1)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.C([O-])([O-])=O.[Na+].[Na+].O>C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].CCOC(C)=O>[CH2:29]([O:36][C:37]1[C:42]([C:2]2[C:7]3[N:8]([CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([CH3:27])[CH2:23][CH2:22]4)[C:9]([N:11]4[CH2:16][CH2:15][O:14][C@@H:13]5[CH2:17][CH2:18][CH2:19][C@@H:12]45)=[N:10][C:6]=3[CH:5]=[C:4]([Cl:28])[N:3]=2)=[CH:41][C:40]([Cl:46])=[CH:39][N:38]=1)[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Komponenten

7

Edukt 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 53216265(2-(Benzyloxy)-5-chloropyridin-3-yl)boronic acidHCID 178461234HCID 178461234, Verbindung

Produkt 1

HCID 178461233HCID 178461233, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418228Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)KatalysatorHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

4,6-dichloro-2-[(trans)-hexahydrocyclopenta[b][1,4]oxazin-4(4aH)-yl]-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridine (racemic, 460 mg, 1.08 mmol), (2-(benzyloxy)-5-chloropyridin-3-yl)boronic acid (purchased from Combi-Blocks Inc.; 372 mg, 1.41 mmol) and 2M aqueous Na2CO3 (5 mL, 10 mmol) were added to degassed 1,2-dimethoxyethane (15 mL), followed by the addition of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (159 mg, 0.2 mmol). The reaction was heated at 90° C. for 6 hours. Water and EtOAc were added. The aqueous layer was extracted several times with EtOAc. The combined organic layers were dried over anhydrous Na2SO4, filtered, and concentrated in vacuo. The residue was purified on a silica gel column (0 to 30% EtOAc/hexanes) to afford 4-[2-(benzyloxy)-5-chloropyridin-3-yl]-6-chloro-2-[(trans)-hexahydrocyclopenta[b][1,4]oxazin-4(4aH)-yl]-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridine (racemic). MS ES calc'd. for C33H37Cl2N5O2 [M+H]+ 606. found 606.

Aufarbeitung

  1. customto degassed 1,2-dimethoxyethane (15 mL)
  2. extractionThe aqueous layer was extracted several times with EtOAc
  3. dry with materialThe combined organic layers were dried over anhydrous Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. customThe residue was purified on a silica gel column (0 to 30% EtOAc/hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-acb384fc9b2447aa9505d731daf19ad5
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846657B2

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