Morpholine → 4-(5-Chloro-2-trifluoromethyl-benzenesulfonyl)-morpholine

HRID 81484Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 81484
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]([F:15])([F:14])[F:13])=[C:6]([S:8](Cl)(=[O:10])=[O:9])[CH:7]=1.[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]([F:15])([F:14])[F:13])=[C:6]([S:8]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)(=[O:10])=[O:9])[CH:7]=1

Komponenten

4

Edukt 2

HCID 8083MorpholineHCID 866319035-Chloro-2-(trifluoromethyl)benzene-1-sulfonyl chloride

Produkt 1

HCID 686302274-(5-Chloro-2-trifluoromethyl-benzenesulfonyl)-morpholine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

5-Chloro-2-trifluoromethyl-benzenesulfonyl chloride (0.17 g, 0.62 mmol) is added to a solution of morphline (0.114 ml, 1.3 mol) in DCM (5 ml) and the resulting white suspension is stirred at room temperature overnight. The reaction mixture is diluted with DCM (5 ml), and washed with 0.1M HCl, dried (MgSO4) and concentrated in vacuo to yield the title compound. [M+H]+ 330.

Aufarbeitung

  1. washwashed with 0.1M HCl
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-45708f4f8412433482efb34a2569e6cb
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846687B2

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