Tetrahydrofuran → 6-Fluoro-5-methylpyridin-3-ol

HRID 81648

Reaktionsgleichung

Reaktionsgleichung von HRID 81648
O.OO.[O:4]1CCCC1.[F:9][C:10]1[C:15]([CH3:16])=[CH:14][C:13](B(O)O)=[CH:12][N:11]=1>O>[F:9][C:10]1[N:11]=[CH:12][C:13]([OH:4])=[CH:14][C:15]=1[CH3:16]

Komponenten

5

Edukt 3

HCID 8028TetrahydrofuranHCID 449047Hydrogen peroxide waterHCID 17750247(6-Fluoro-5-methylpyridin-3-yl)boronic acid

Produkt 1

HCID 229897166-Fluoro-5-methylpyridin-3-olAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Hydrogen peroxide water (4.37 ml, 42.8 mmol) was added to a tetrahydrofuran solution (50 ml) of 2-fluoro-3-methylpyridine-5-boronic acid (5.1 g, 32.9 mmol), and stirred overnight at room temperature. Water was added to the reaction solution, and extracted with ethyl acetate. The organic layer was washed with aqueous 5% sodium thiosulfate solution and saturated saline water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain 6-fluoro-5-methylpyridin-3-ol (4.03 g, yield: 96%) as a pale yellow solid.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with aqueous 5% sodium thiosulfate solution and saturated saline water
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-c132c5997e2244ff9e51b0e267c433e3
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846700B2

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