Benzaldehyde → Phenyl methoxymethyl cinnamonitrile
Reaktionsgleichung
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9](#[N:12])[CH:10]=[CH2:11].[CH3:13][O-:14].[Na+]>>[C:2]1([C:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[C:10]([CH2:11][O:14][CH3:13])[C:9]#[N:12])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Komponenten
4
Versuchsvorschrift
In the procedure of Scheme C, benzaldehyde a is treated with acrylonitrile in the presence of sodium methoxide in step 1 to afford a phenyl methoxymethyl cinnamonitrile compound q, which in turn is reacted with guanidine in step 2 to yield the diaminopyrimidine r. Diamino pyrimidine r is a compound of formula (I) in which X is —CH2—, Y is —NH2 and R6, R7 and R8 are hydrogen.
Quellen und Nachweise
- ORD-Eintrag
- ord-a192201c1e914707b44acbd87a3f89da
- Quelldatensatz
- uspto-grants-2014_09
- Patentnummer
- US08846705B2
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