Water → 4-({3-[(2,6-Diethylphenyl)carbamoyl]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazolin-8-yl}amino)-3-methoxybenzoic acid

HRID 81957Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 81957
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][CH3:10])[C:4]=1[NH:11][C:12]([C:14]1[C:18]2[CH2:19][CH2:20][C:21]3[CH:22]=[N:23][C:24]([NH:27][C:28]4[CH:40]=[CH:39][C:31]([C:32]([O:34]C(C)(C)C)=[O:33])=[CH:30][C:29]=4[O:41][CH3:42])=[N:25][C:26]=3[C:17]=2[N:16]([CH3:43])[N:15]=1)=[O:13])[CH3:2].O>CN(C)C=O.FC(F)(F)C(O)=O>[CH2:9]([C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([CH2:1][CH3:2])[C:4]=1[NH:11][C:12]([C:14]1[C:18]2[CH2:19][CH2:20][C:21]3[CH:22]=[N:23][C:24]([NH:27][C:28]4[CH:40]=[CH:39][C:31]([C:32]([OH:34])=[O:33])=[CH:30][C:29]=4[O:41][CH3:42])=[N:25][C:26]=3[C:17]=2[N:16]([CH3:43])[N:15]=1)=[O:13])[CH3:10]

Komponenten

5

Edukt 2

HCID 962WaterHCID 44556274HCID 44556274, Verbindung

Produkt 1

HCID 445562754-({3-[(2,6-Diethylphenyl)carbamoyl]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazolin-8-yl}amino)-3-methoxybenzoic acidAusbeute 99,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

To a solution of tert-butyl 4-({3-[(2,6-diethylphenyl)carbamoyl]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazolin-8-yl}amino)-3-methoxybenzoate (500 mg, 0.857 mmol) in dimethylformamide (8 mL), trifluoro acetic acid (0.600 mL), were added. The mixture was stirred at room temperature overnight. Water was added and the mixture extracted with ethylacetate. The organic solvent evaporated to dryness. To give 450 mg of the title compound in quantitative yield.

Aufarbeitung

  1. extractionthe mixture extracted with ethylacetate
  2. customThe organic solvent evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-f80374362ca74d7685d956d32bad6840
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846701B2

Notizen zur Reaktion

Wird geladen…