HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 82086Erstellt: 25. Oktober 2026
4-Methylmorpholine → 2-[5-Fluoro-2-(trifluoromethyl)phenyl]-N-{5-[(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)carbonyl]pyridin-3-yl}acetamide
https://huagongshe.com/reaction/82086
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 4-Methylmorpholine | HCID 7972 | — |
| Edukt | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Edukt | 5-Fluoro-2-(Trifluoromethyl)Phenylacetic Acid | HCID 2737594 | — |
| Edukt | (5-aminopyridin-3-yl)(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone | HCID 70817432 | — |
| Lösungsmittel | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Produkt | 2-[5-Fluoro-2-(trifluoromethyl)phenyl]-N-{5-[(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)carbonyl]pyridin-3-yl}acetamide | HCID 70817499 | — |
Reaktionsschritte
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide HCl (150 μL, 0.5M in DMF) was added to 5-fluoro-2-(trifluoromethyl)phenylacetic acid (90 μmol), N-methylmorpholine (25 μL, 150 μmol), 1-hydroxybenzotriazole (15 μmol, 0.05M in DMF) and (5-aminopyridin-3-yl)(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone (Preparation 110, 75 μmol, 0.25 M in DMF). The mixture was stirred at 50° C. for 2 hours and then evaporated in vacuo and purified by prep-HPLC (method 4) to afford the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08846698B2 |
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| Quelldatensatz | uspto-grants-2014_09 |
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| ORD ID | ord-d7c1f637f0a44de9991d5d7951cd7aaf |
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| Quellennotiz | uspto-grants-2014_09 |
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