HRID82086

反应详情

EQUATION

反应方程式

HRID 82086 的结构方程式

AUXILIARIES

试剂、催化剂与溶剂

1

CONDITIONS

反应条件

温度
50 °C

PROCEDURE

实验过程

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide HCl (150 μL, 0.5M in DMF) was added to 5-fluoro-2-(trifluoromethyl)phenylacetic acid (90 μmol), N-methylmorpholine (25 μL, 150 μmol), 1-hydroxybenzotriazole (15 μmol, 0.05M in DMF) and (5-aminopyridin-3-yl)(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone (Preparation 110, 75 μmol, 0.25 M in DMF). The mixture was stirred at 50° C. for 2 hours and then evaporated in vacuo and purified by prep-HPLC (method 4) to afford the title compound.

WORKUP

后处理

  1. customevaporated in vacuo
  2. custompurified by prep-HPLC (method 4)