N-Iodosuccinimide → 2-chloro-5-iodo-7H-pyrrolo(2,3-d)pyrimidine

HRID 82156Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 82156
[I:1]N1C(=O)CCC1=O.[Cl:9][C:10]1[N:11]=[CH:12][C:13]2[CH:18]=[CH:17][NH:16][C:14]=2[N:15]=1.S(S([O-])=O)([O-])(=O)=O.[Na+].[Na+]>C(#N)C>[Cl:9][C:10]1[N:11]=[CH:12][C:13]2[C:18]([I:1])=[CH:17][NH:16][C:14]=2[N:15]=1

Komponenten

5

Edukt 3

HCID 120273N-IodosuccinimideHCID 656671Sodium PyrosulfiteHCID 57067742-Chloro-7H-pyrrolo[2,3-d]pyrimidine

Produkt 1

HCID 529112452-chloro-5-iodo-7H-pyrrolo(2,3-d)pyrimidineAusbeute 82 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

N-Iodosuccinimide (742 g, 3.30 mol) was added to 2-chloro-7H-pyrrolo[2,3-d]pyrimidine (482.5 g, 3.14 mol) in acetonitrile (2500 mL) at 12° C. The mixture was stirred at room temperature for 1 hour then sodium metabisulphite (650 g in 4500 mL of water) was added. The mixture was stirred for 1 hour then filtered to afford the title compound as a orange solid in 82% yield, 716.2 g.

Aufarbeitung

  1. stirringThe mixture was stirred for 1 hour
  2. filtrationthen filtered

Quellen und Nachweise

ORD-Eintrag
ord-3d72ddf0a4204e41a42a87d18da72d71
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846698B2

Notizen zur Reaktion

Wird geladen…