Lithium Hydroxide → HCID 86672138, Verbindung
Reaktionsgleichung
[CH3:1][O:2][CH2:3][C:4]1[N:8]([CH3:9])[N:7]=[C:6]([C:10]([O:12]CC)=[O:11])[CH:5]=1.[Li+].[OH-]>CO>[CH3:1][O:2][CH2:3][C:4]1[N:8]([CH3:9])[N:7]=[C:6]([C:10]([OH:12])=[O:11])[CH:5]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of ethyl 5-(methoxymethyl)-1-methyl-1H-pyrazole-3-carboxylate (WO9743277) (177 mg, 0.893 mmol) in MeOH, a 0.5 M solution of LiOH was added (5.3 mL, 2.68 mmol). The reaction was stirred at room temperature overnight. The solution was evaporated to dryness and the residue was adjusted to pH5 with a 2 N HCl solution. The aqueous solution was extracted with EtOAc and the organic layer was dried over Na2SO4 and evaporated in vacuo to give the title compound as a white solid 95%, 145 mg.
Aufarbeitung
- customThe solution was evaporated to dryness
- extractionThe aqueous solution was extracted with EtOAc
- dry with materialthe organic layer was dried over Na2SO4
- customevaporated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-f7b2a6feb4c7410d84bd9f7e300efde1
- Quelldatensatz
- uspto-grants-2014_09
- Patentnummer
- US08846698B2
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