Trifluoroacetic acid → Amino-acetic acid 4-allyl-2-methoxy-phenyl ester Trifluoroacetate

HRID 82491

Reaktionsgleichung

Reaktionsgleichung von HRID 82491
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11](=[O:14])[CH2:12][NH2:13])=[C:6]([O:15][CH3:16])[CH:5]=1)[CH:2]=[CH2:3].[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>C(Cl)Cl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11](=[O:14])[CH2:12][NH2:13])=[C:6]([O:15][CH3:16])[CH:5]=1)[CH:2]=[CH2:3]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 69920127Amino-acetic acid 4-allyl-2-methoxy-phenyl ester

Produkt 1

HCID 86674925Amino-acetic acid 4-allyl-2-methoxy-phenyl ester Trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

To a solution of compound amino-acetic acid 4-allyl-2-methoxy-phenyl ester (0.3 g) in DCM (10 mL) was added trifluoroacetic acid (0.5 mL) drop wise at (0° C.). The mixture was allowed to stir at room temperature (25° C.) over a period of 2 h. Solvent was stripped off completely and the reaction was carried for the next step (510 mg).

Quellen und Nachweise

ORD-Eintrag
ord-94416477fee4402b9dae8b9b83cdb00f
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846721B2

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