Water → HCID 52950664, Verbindung

HRID 83020

Reaktionsgleichung

Reaktionsgleichung von HRID 83020
[OH-].[Na+:2].[O:3]=[C:4]1[NH:9][C:8]2[N:10]=[CH:11][C:12](/[CH:14]=[CH:15]/[C:16](=[O:28])[N:17]3[CH2:20][CH:19]([O:21][CH2:22][C:23]4[S:24][CH:25]=[CH:26][CH:27]=4)[CH2:18]3)=[CH:13][C:7]=2[CH2:6][N:5]1[CH2:29][C:30]([O:32]CC)=[O:31].O>CO>[O:3]=[C:4]1[NH:9][C:8]2[N:10]=[CH:11][C:12](/[CH:14]=[CH:15]/[C:16](=[O:28])[N:17]3[CH2:20][CH:19]([O:21][CH2:22][C:23]4[S:24][CH:25]=[CH:26][CH:27]=4)[CH2:18]3)=[CH:13][C:7]=2[CH2:6][N:5]1[CH2:29][C:30]([O-:32])=[O:31].[Na+:2]

Komponenten

5

Edukt 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 68338152(E)-Ethyl 2-(2-oxo-6-(3-oxo-3-(3-(thiophen-2-ylmethoxy)azetidin-1-yl)prop-1-enyl)-1,2-dihydropyrido[2,3-d]pyrimidin-3(4H)-yl)acetate

Produkt 1

HCID 52950664HCID 52950664, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of sodium hydroxide (1N, 438 μL, 0.44 mmol) was added to a suspension of (E)-ethyl 2-(2-oxo-6-(3-oxo-3-(3-(thiophen-2-ylmethoxy)azetidin-1-yl)prop-1-enyl)-1,2-dihydropyrido[2,3-d]pyrimidin-3(4H)-yl)acetate (100 mg, 0.22 mmol) in methanol (5 mL) at room temperature. The reaction mixture was refluxed for 15 minutes then poured into cold water. The resulting precipitate was filtered and washed with diethyl ether. The title product was obtained as a white solid (53.5 mg, 54%).

Aufarbeitung

  1. temperatureThe reaction mixture was refluxed for 15 minutes
  2. filtrationThe resulting precipitate was filtered
  3. washwashed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-33b201f5a01b498eadf45c09e2a1cfbc
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846711B2

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