Bromine → 4-Bromo-2,6-difluoropyridine

HRID 8304

Reaktionsgleichung

[F:1][C:2]1[CH:7]=[C:6](B(O)O)[CH:5]=[C:4]([F:11])[N:3]=1.FC1C=C(NN)C=C(F)N=1.[Br:22]Br>>[Br:22][C:6]1[CH:7]=[C:2]([F:1])[N:3]=[C:4]([F:11])[CH:5]=1

Komponenten

Edukt 3

HCID 24408Bromine

HCID 27627472,6-Difluoropyridine-4-boronic acid

HCID 121758102,6-Difluoro-4-hydrazinylpyridine

Produkt 1

HCID 220155594-Bromo-2,6-difluoropyridine

Versuchsvorschrift

The second step in the synthetic procedure used in synthesizing the 2,6-difluoropyridin-4-ylboronic acid involves bromination of 2,6-difluoro-4-hydrazinopyridine by elemental bromine to produce 4-bromo-2,6-difluoropyridine. This reaction can be depicted as follows:

Quellen und Nachweise

ORD-Eintrag: ord-b56817fc57374cc58bfa3e46d9d16bc2
Quelldatensatz: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07087755B1

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