Trifluoroacetic acid → HCID 86680395, Verbindung

HRID 83587Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 83587
COC1C=C(OC)C=CC=1C[N:6]1[CH2:12][CH:11]([C:13]([OH:15])=[O:14])[C:8]2([CH2:10][CH2:9]2)[C:7]1=[O:16].C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O>>[O:16]=[C:7]1[NH:6][CH2:12][CH:11]([C:13]([OH:15])=[O:14])[C:8]21[CH2:9][CH2:10]2

Komponenten

4

Edukt 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 866803935-(2,4-Dimethoxybenzyl)-4-oxo-5-azaspiro[2.4]heptane-7-carboxylic Acid

Produkt 1

HCID 86680395HCID 86680395, VerbindungAusbeute 76,2 %

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To an optically active compound of 5-(2,4-dimethoxybenzyl)-4-oxo-5-azaspiro[2.4]heptane-7-carboxylic acid (372 mg) were sequentially added anisole (159 μl) and trifluoroacetic acid (5.6 ml) at room temperature, and the mixture was stirred at 80° C. for 4 hours. This reaction mixture was concentrated under reduced pressure, and diisopropyl ether (10 ml) was added thereto. The precipitated solid was collected by filtration to give the titled compound (144 mg).

Aufarbeitung

  1. customat room temperature
  2. concentrationThis reaction mixture was concentrated under reduced pressure, and diisopropyl ether (10 ml)
  3. additionwas added
  4. filtrationThe precipitated solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-a82509e990c64154b0a3ed9534001621
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846746B2

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