Hydrochloric Acid → 1-[(4-Chlorophenyl)methyl]-1H-imidazole-2-carboxylic acid

HRID 83659Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 83659
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][N:7]2[CH:11]=[CH:10][N:9]=[C:8]2[C:12]([O:14]CC)=[O:13])=[CH:4][CH:3]=1.[OH-].[Na+].O.Cl>CCO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[CH:11]=[CH:10][N:9]=[C:8]2[C:12]([OH:14])=[O:13])=[CH:17][CH:18]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 68379775ethyl 1-(4-chlorobenzyl)-1H-imidazole-2-carboxylate

Produkt 1

HCID 683797411-[(4-Chlorophenyl)methyl]-1H-imidazole-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Ethyl 1-(4-chlorobenzyl)-1H-imidazole-2-carboxylate (7.28 g, 27.5 mmol), was dissolved in EtOH (10 mL) and 10% aq. NaOH (20 mL) and stirred at rt for 15 h. The solvent was then stripped off, water was added, and the solution acidified with HCl. The resulting precipitate was collected over a filter and washed with 1M HCl and dried to afford the title compound as a white powder without further characterization. (Yield: 6.506 g, 27.5 mmol, 100%)

Aufarbeitung

  1. customThe resulting precipitate was collected over
  2. filtrationa filter
  3. washwashed with 1M HCl
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a420a9d85db14e7db51511543c07ec47
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846684B2

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