Water → (2,2-Difluoro-1,3-dioxaindan-5-yl)methanol

HRID 83689

Reaktionsgleichung

Reaktionsgleichung von HRID 83689
C[O:2][C:3]([C:5]1[CH:15]=[CH:14][C:8]2[O:9][C:10]([F:13])([F:12])[O:11][C:7]=2[CH:6]=1)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>O1CCCC1>[F:13][C:10]1([F:12])[O:9][C:8]2[CH:14]=[CH:15][C:5]([CH2:3][OH:2])=[CH:6][C:7]=2[O:11]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 591292611,3-Benzodioxole-5-carboxylic acid, 2,2-difluoro-, methyl ester

Produkt 1

HCID 12814281(2,2-Difluoro-1,3-dioxaindan-5-yl)methanolAusbeute 76 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

Crude 2,2-difluoro-benzo[1,3]dioxole-5-carboxylic acid methyl ester (11.5 g) dissolved in 20 mL of anhydrous tetrahydrofuran (THF) was slowly added to a suspension of lithium aluminum hydride (4.10 g, 106 mmol) in anhydrous THF (100 mL) at 0° C. The mixture was then warmed to room temperature. After being stirred at room temperature for 1 hour, the reaction mixture was cooled to 0° C. and treated with water (4.1 g), followed by sodium hydroxide (10% aqueous solution, 4.1 mL). The resulting slurry was filtered and washed with THF. The combined filtrate was evaporated to dryness and the residue was purified by silica gel column chromatography to give (2,2-difluoro-benzo[1,3]dioxol-5-yl)-methanol (7.2 g, 76% over two steps) as a colorless oil.

Aufarbeitung

  1. temperaturethe reaction mixture was cooled to 0° C.
  2. filtrationThe resulting slurry was filtered
  3. washwashed with THF
  4. customThe combined filtrate was evaporated to dryness
  5. customthe residue was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-9cf768c6b7b44a5c9809c7e0755164f6
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846753B2

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