Piperidine → 4-Piperidinylbut-1-ene

Reaktionsgleichung

Br[CH2:2][CH2:3][CH:4]=[CH2:5].[NH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1>>[N:6]1([CH2:7][CH2:8][CH:9]=[CH2:10])[CH2:11][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

Edukt 2

HCID 8082Piperidine

HCID 21241Homoallyl bromide

Produkt 1

HCID 45622824-Piperidinylbut-1-eneAusbeute 93,4 %

Versuchsvorschrift

4-Bromobut-1-ene (1.35 g) was treated with piperidine (1.7 g) and heated at reflux for 3 hours. The mixture was cooled to ambient temperature, filtered and the residue washed with ether (50 mL). The combined filtrate and washings were evaporated to give the title compound (1.3 g).

Aufarbeitung

temperatureheated
temperatureat reflux for 3 hours
filtrationfiltered
washthe residue washed with ether (50 mL)
customThe combined filtrate and washings were evaporated

Quellen und Nachweise

ORD-Eintrag: ord-d7ef957ab1cf46f68f1f4c42cdc7ceea
Quelldatensatz: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07087757B2

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