Isobutyl piperazine-1-carboxylate → 4-(5,6-Dimethoxy-2-benzimidazolyl) piperazine-1-carboxylic acid isobutyl ester-hydrochloride

HRID 838967Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 838967
[Cl:1][C:2]1[NH:3][C:4]2[CH:10]=[C:9]([O:11][CH3:12])[C:8]([O:13][CH3:14])=[CH:7][C:5]=2[N:6]=1.[CH2:15]([O:19][C:20]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)=[O:21])[CH:16]([CH3:18])[CH3:17]>COCCO>[ClH:1].[CH2:15]([O:19][C:20]([N:22]1[CH2:27][CH2:26][N:25]([C:2]2[NH:3][C:4]3[CH:10]=[C:9]([O:11][CH3:12])[C:8]([O:13][CH3:14])=[CH:7][C:5]=3[N:6]=2)[CH2:24][CH2:23]1)=[O:21])[CH:16]([CH3:18])[CH3:17]

Komponenten

4

Edukt 2

HCID 11788701Isobutyl piperazine-1-carboxylateHCID 203255242-Chloro-5,6-dimethoxy-1H-benzo[d]imidazole

Produkt 1

HCID 706191224-(5,6-Dimethoxy-2-benzimidazolyl) piperazine-1-carboxylic acid isobutyl ester-hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80192-MethoxyethanolLösungsmittel

Versuchsvorschrift

3.40 g 2-chloro-5,6-dimethoxy benzimidazole, 7.50 g piperazine N-carboxylic acid isobutyl ester (described in U.S. 3,635,979, Example LVII) and 25 ml 2-methoxyethanol were reacted as in Example I to give the base of the desired product as a gum. This was washed free of starting amine with water, then dissolved in isopropyl alcohol and acidified with HCl gas to give 5.30 g product HCl salt, mp 248°-250° C

Quellen und Nachweise

ORD-Eintrag
ord-1df8af20ef9f457396ece11f968bd90b
Quelldatensatz
uspto-grants-1978_06
Patentnummer
US04093726

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