Hydrochloric Acid → 5-Oxo-1-(4-sulfophenyl)pyrazolidine-3-carboxylic acid

HRID 839422

Reaktionsgleichung

Reaktionsgleichung von HRID 839422
[C:1]([O:8]CC)(=O)/[CH:2]=[CH:3]\[C:4]([O-:6])=[O:5].[NH:11]([C:13]1[CH:18]=[CH:17][C:16]([S:19]([O-:22])(=[O:21])=[O:20])=[CH:15][CH:14]=1)[NH2:12].C(=O)([O-])[O-].[Na+].[Na+].Cl>O>[C:4]([CH:3]1[CH2:2][C:1](=[O:8])[N:11]([C:13]2[CH:18]=[CH:17][C:16]([S:19]([OH:22])(=[O:20])=[O:21])=[CH:15][CH:14]=2)[NH:12]1)([OH:6])=[O:5]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 10340Sodium Carbonate2×HCID 1549500p-Hydrazinobenzene sulphonateHCID 86733784(Z)-4-ethoxy-4-oxobut-2-enoate

Produkt 1

HCID 203245745-Oxo-1-(4-sulfophenyl)pyrazolidine-3-carboxylic acidAusbeute 76 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

2 parts of monoethyl maleate are added with stirring to 25 parts of water containing 2 parts of p-hydrazinobenzene sulphonate and 1 part of sodium carbonate. The mixture is heated at 100° C for 5 hours. The resulting solution is warmed with sodium carbonate and the pH finally adjusted to 3-4 with hydrochloric acid. The 3carboxy-1-(4'-sulphophenyl)-5-pyrazolidone thus formed is filtered off and dried between 50°-100° C. The actual weight yield is 4 parts of strength 74% (determined by N.M.R.) which represents a yield of 76%.

Quellen und Nachweise

ORD-Eintrag
ord-534efe0925824e2dae91070e5941e854
Quelldatensatz
uspto-grants-1978_06
Patentnummer
US04095024

Verknüpfte Notizen

Wird geladen…