2-Pyridinamine, 5-iodo- → 5-phenoxypyridin-2-amine

HRID 839635

Reaktionsgleichung

Reaktionsgleichung von HRID 839635
[C:1]1([O-:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[K+].[NH2:9][C:10]1[CH:15]=[CH:14][C:13](I)=[CH:12][N:11]=1>CC(N(C)C)=O>[NH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:12][N:11]=1

Komponenten

4

Edukt 2

HCID 885792-Pyridinamine, 5-iodo-HCID 23670670Potassium phenoxide

Produkt 1

HCID 221794545-phenoxypyridin-2-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31374DimethylacetamideLösungsmittel

Versuchsvorschrift

3.3 G. of potassium phenolate, 5.47 g. of 2-amino 5-iodopyridine and 1.78 g. of cuprous oxide in 150 ml. of dimethylacetamide are heated at reflux under a nitrogen atmosphere for 24 hours. The solvent is removed in vacuo and the residue is extracted with chloroform. Chromatography of the methylene chloride soluble portion with silica gel and elution with ethyl acetate yields 2-amino-5-phenoxy pyridine m.p. 67°-69° C.

Aufarbeitung

  1. temperatureat reflux under a nitrogen atmosphere for 24 hours
  2. customThe solvent is removed in vacuo
  3. extractionthe residue is extracted with chloroform
  4. washChromatography of the methylene chloride soluble portion with silica gel and elution with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-eaa44ef71d95469786d79e2ca79f7d0d
Quelldatensatz
uspto-grants-1978_06
Patentnummer
US04096264

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