Water → 1-[3-(Chloromethyl)benzoyl]piperidine
Reaktionsgleichung
[Cl:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](Cl)=[O:7].[NH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1.O>C(N(CC)CC)C>[Cl:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:7]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 5 °C
Versuchsvorschrift
3-Chloromethylbenzoyl chloride (1.45 ml) was added to a solution of piperidine (1 ml) in triethylamine (2 ml) and the mixture was stirred under nitrogen at 5° C. for 45 min. Water was added, the product was extracted with dichloromethane and the extract was washed with water, dried over sodium sulphate and evaporated to give 1(3-chloromethylbenzoyl)piperidine (2.32 g) as an oil.
Aufarbeitung
- extractionthe product was extracted with dichloromethane
- washthe extract was washed with water
- dry with materialdried over sodium sulphate
- customevaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-9c49d763d0b545c889c9a7bf960a8df2
- Quelldatensatz
- uspto-grants-2002_04
- Patentnummer
- US06365604B1
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