Water → Benzoic acid, 4-iodo-2-methoxy-, methyl ester

HRID 840465

Reaktionsgleichung

Reaktionsgleichung von HRID 840465
[H-].[Na+].[OH:3][C:4]1[CH:13]=[C:12]([I:14])[CH:11]=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7].I[CH3:16].O>CN(C=O)C>[I:14][C:12]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([O:3][CH3:16])[CH:13]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 11380407Methyl 4-iodosalicylate

Produkt 1

HCID 22619468Benzoic acid, 4-iodo-2-methoxy-, methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel2×

Versuchsvorschrift

238 mg (7.9 mmol) of sodium hydride (80% in oil) and 20 ml of DMF were introduced into a three-necked flask, a solution of 2 g (7.2 mmol) of methyl 2-hydroxy-4-iodobenzoate in 50 ml of DMF was added dropwise and stirring was carried out until gas evolution had ceased. 540 μl (8.6 mmol) of iodomethane were then added and stirring was carried out at room temperature for two hours. The reaction mixture was poured into water and extracted with ethyl ether. The organic phase was separated by settling, dried over magnesium sulfate and evaporated. 2.1 g (100%) of methyl 4-iodo-2-methoxybenzoate were recovered.

Aufarbeitung

  1. stirringstirring
  2. extractionextracted with ethyl ether
  3. customThe organic phase was separated
  4. dry with materialdried over magnesium sulfate
  5. customevaporated
  6. custom2.1 g (100%) of methyl 4-iodo-2-methoxybenzoate were recovered

Quellen und Nachweise

ORD-Eintrag
ord-69bf23ee3d6d4e13bfb342b1c7246429
Quelldatensatz
uspto-grants-2002_04
Patentnummer
US06368608B1

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