5-Methoxy-3-(4-nitrophenyl)-1,3,4-oxadiazol-2(3H)-one → 3-(4-Aminophenyl)-5-methoxy-1,3,4-oxadiazol-2(3H)-one

HRID 840726Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 840726
[CH3:1][O:2][C:3]1[O:7][C:6](=[O:8])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=2)[N:4]=1.[H][H]>[Pd].CO>[CH3:1][O:2][C:3]1[O:7][C:6](=[O:8])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[N:4]=1

Komponenten

5

Edukt 2

HCID 102361585-Methoxy-3-(4-nitrophenyl)-1,3,4-oxadiazol-2(3H)-oneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 99207173-(4-Aminophenyl)-5-methoxy-1,3,4-oxadiazol-2(3H)-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture consisting of 1.4 g of 5-methoxy-3-(4-nitrophenyl)-3H-(1,3,4)oxadiazol-2-one, 0.5 g of Pd/C and 20ml of methanol was hydrogenated under atmospheric pressure at room temperature until the calculated amount of hydrogen had been taken up. The catalyst was then filtered off, and the solution was concentrated in vacuo. The remaining semisolid residue was stirred with isopropanol and filtered off with suction.

Aufarbeitung

  1. filtrationThe catalyst was then filtered off
  2. concentrationthe solution was concentrated in vacuo
  3. filtrationfiltered off with suction

Quellen und Nachweise

ORD-Eintrag
ord-c9fe2b85bfef4974a91af7e163da366c
Quelldatensatz
uspto-grants-2002_04
Patentnummer
US06369088B2

Notizen zur Reaktion

Wird geladen…