Benzylamine → HCID 178418897, Verbindung

HRID 8412

Reaktionsgleichung

Reaktionsgleichung von HRID 8412
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)S(O[Si](C)(C)C)(=O)=O.[OH-].[Na+].[CH2:23]([S:25][C:26]#[N:27])[CH3:24]>>[CH2:1]([NH:8][C:26](=[NH:27])[S:25][CH2:23][CH3:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 4

HCID 7504BenzylamineHCID 10968Ethyl thiocyanateHCID 14798Sodium HydroxideHCID 65367Trimethylsilyl triflate

Produkt 1

HCID 178418897HCID 178418897, VerbindungAusbeute 100 %

Versuchsvorschrift

Benzylamine (13.8 mg) was dissolved in ethyl thiocyanate (50 μl). To this solution, trimethylsilyl trifluoromethanesulfonate (25.7 μl) was added dropwise at room temperature. After continued stirring for 1 day at room temperature, 2N aqueous sodium hydroxide was added to the solution, which was then extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the titled compound (25.4 mg, yield 100%).

Aufarbeitung

  1. extractionwas then extracted with ethyl acetate
  2. dry with materialThe ethyl acetate layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7db99835b713471dac9c78ee60d5003c
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087783B2

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