Phosphorus pentachloride → (1-Methyl-7-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroquinol-4-yl)-methane-sulfonic acid chloride

Reaktionsgleichung

[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13][CH3:14])[CH:11]=2)[C:6]([CH2:15][S:16](O)(=[O:18])=[O:17])=[CH:5][C:4]1([CH3:21])[CH3:20])C.CN1C2C(=CC=C(OC)C=2)C(CS(O)(=O)=O)CC1(C)C.P(Cl)(Cl)(Cl)(Cl)[Cl:43]>>[CH3:1][N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13][CH3:14])[CH:11]=2)[CH:6]([CH2:15][S:16]([Cl:43])(=[O:18])=[O:17])[CH2:5][C:4]1([CH3:21])[CH3:20]

Komponenten

Edukt 3

HCID 24819Phosphorus pentachloride

HCID 12138186(1-Methyl-7-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroquinol-4-yl)-methanesulfonic acid

HCID 12138189(1-Ethyl-7-methoxy-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid

Produkt 1

HCID 12138193(1-Methyl-7-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroquinol-4-yl)-methane-sulfonic acid chlorideAusbeute 78 %

Versuchsvorschrift

(1-Methyl-7-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroquinol-4-yl)-methane-sulfonic acid chloride (19) is prepared similarly to compound (16) using compound (3) and phosphorus pentachloride except that it is stirred for 18 hours at room temperature.

Quellen und Nachweise

ORD-Eintrag: ord-50b7afeb948d43a2a465233e574e860a
Quelldatensatz: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08846924B2

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