Water → Furan-2-acetic acid

HRID 842302

Reaktionsgleichung

Reaktionsgleichung von HRID 842302
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]#N.[OH-:9].[K+].[OH2:11]>>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([OH:11])=[O:9]

Komponenten

4

Edukt 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 109095152-Furanacetonitrile

Produkt 1

HCID 75974Furan-2-acetic acid

Versuchsvorschrift

A mixture of 2-furanacetonitrile (6.14 g), KOH (4.0 g), and water (25 mL) was refluxed for 1 hour and then cooled. Following extraction with ether, the aqueous layer was acidified to pH 2.0 with concentrated aqueous HCl. This solution was extracted with ether, and the organic phase was dried over MgSO4 and evaporated under vacuum to yield 2-furanacetic acid. The structure of the product was confirmed by NMR.

Aufarbeitung

  1. temperaturewas refluxed for 1 hour
  2. temperaturecooled
  3. extractionextraction with ether
  4. extractionThis solution was extracted with ether
  5. dry with materialthe organic phase was dried over MgSO4
  6. customevaporated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-e04ded5e86414da0b6241c4fcbfbb6f8
Quelldatensatz
uspto-grants-2002_04
Patentnummer
US06372895B1

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