Water → 3-Chloro-2-cyanopyrazine 1-oxide

HRID 842617

Reaktionsgleichung

Reaktionsgleichung von HRID 842617
[Cl:1][C:2]1[C:7]([C:8]#[N:9])=[N:6][CH:5]=[CH:4][N:3]=1.[OH2:10]>OS(O)(=O)=O>[Cl:1][C:2]1[C:7]([C:8]#[N:9])=[N+:6]([O-:10])[CH:5]=[CH:4][N:3]=1

Komponenten

4

Edukt 2

HCID 962WaterHCID 2924653-Chloropyrazine-2-carbonitrile

Produkt 1

HCID 107969923-Chloro-2-cyanopyrazine 1-oxide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

2-Chloro-3-cyanopyrazine (5.00 g, 35.94 mmol) in concentrated H2SO4 (35 mL) at 0° C. was treated portionwise with K2S2O8 (11.65 g, 43.95 mmol), warmed to room temperature, stirred for 24 hours, treated with water, and extracted with chloroform. The organic extract was washed sequentially with water, saturated NaHCO3 and brine, dried (MgSO4) and concentrated to provide the title compound. MS (DCI/NH3) m/e 173 (M+NH4)+.

Aufarbeitung

  1. extractionextracted with chloroform
  2. extractionThe organic extract
  3. washwas washed sequentially with water, saturated NaHCO3 and brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-aff5277d64c849fdb0f118686d72d8e9
Quelldatensatz
uspto-grants-2002_04
Patentnummer
US06376488B1

Verknüpfte Notizen

Wird geladen…