Triethylamine → 3-amino-1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile

HRID 842707

Reaktionsgleichung

O.[NH2:2][NH2:3].Cl[C:5]1[C:10]([C:11]#[N:12])=[CH:9][C:8]([C:13]#[N:14])=[CH:7][N:6]=1.C(N(CC)CC)C>C(O)C>[C:13]([C:8]1[CH:9]=[C:10]2[C:5](=[N:6][CH:7]=1)[NH:3][N:2]=[C:11]2[NH2:12])#[N:14]

Komponenten

Reaktionsbedingungen

Temperatur: 60 °C

Versuchsvorschrift

Hydrazine hydrate (55%, 125 μL, 2.20 mmol) was added to a stirred suspension of 2-chloro-3,5-dicyanopyridine (240 mg, 1.47 mmol) and triethylamine (205 μL, 1.47 mmol) in ethanol (3 mL) and the resulting red mixture was heated to 60° C. After 16 h the mixture was cooled and filtered to give the title compound:

Aufarbeitung

temperatureAfter 16 h the mixture was cooled
filtrationfiltered

Quellen und Nachweise

ORD-Eintrag: ord-7bac2a1c9f9e468fa8fa8cecea7a7103
Quelldatensatz: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06376499B1

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