Isopropylamine → 2-Methylpropanoic acid (carboxymethylphosphonomethyl carbamoyloxy)-methyl ester-isopropylamine salt

HRID 843095Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 843095
[C:1]([CH2:4][O:5][P:6]([CH2:9][NH:10][C:11]([O:13][CH2:14][O:15][C:16](=[O:20])[CH:17]([CH3:19])[CH3:18])=[O:12])([OH:8])=[O:7])([OH:3])=[O:2].[CH:21]([NH2:24])([CH3:23])[CH3:22]>CC(C)=O>[CH:21]([NH2:24])([CH3:23])[CH3:22].[C:1]([CH2:4][O:5][P:6]([CH2:9][NH:10][C:11]([O:13][CH2:14][O:15][C:16](=[O:20])[CH:17]([CH3:18])[CH3:19])=[O:12])([OH:8])=[O:7])([OH:3])=[O:2]

Komponenten

4

Edukt 2

HCID 6363IsopropylamineHCID 867579662-Methylpropanoic acid (carboxymethylphosphonomethylcarbamoyloxy)-methyl ester

Produkt 1

HCID 867579682-Methylpropanoic acid (carboxymethylphosphonomethyl carbamoyloxy)-methyl ester-isopropylamine saltAusbeute 90,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a stirred ice cold solution of 2-methylpropanoic acid (carboxymethylphosphonomethylcarbamoyloxy)-methyl ester (14.1 g, 43.8 mmol) in 80 mL of acetone was added isopropylamine (3.71 mL, 43.8 mmol). After 15 min of stirring the solvent was removed was removed under vacuum. The solid was washed with diethyl ether and subsequently dried under vacuum to afford 14.8 g of a tannish solid. 1H-NMR (300 MHz, D2O) δ (ppm): 1.01 (dd, 6H), 1.16 (d, 6H), 2.51 (m, 1H), 3.35 (m, 1H), 3.47 (d, 2H), 4.09 (d, 2H), 5.63 (d, 2H).

Aufarbeitung

  1. customwas removed
  2. customwas removed under vacuum
  3. washThe solid was washed with diethyl ether
  4. customsubsequently dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-e55d0862b0784cba84138ed9f8ca2ffb
Quelldatensatz
uspto-grants-2002_04
Patentnummer
US06376548B1

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