1-o-Benzyl-3-o-t-butyldimethylsilyl-2-o-methyl-rac-glycerol → 1-o-t-Butyldimethylsilyl-2-o-methyl-rac-glycerol

HRID 843568Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 843568
C([O:8][CH2:9][CH:10]([CH2:13][O:14][Si:15]([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16])[O:11][CH3:12])C1C=CC=CC=1>[Pd].CO>[Si:15]([O:14][CH2:13][CH:10]([CH2:9][OH:8])[O:11][CH3:12])([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16]

Komponenten

4

Edukt 1

HCID 223164691-o-Benzyl-3-o-t-butyldimethylsilyl-2-o-methyl-rac-glycerol

Produkt 1

HCID 223164511-o-t-Butyldimethylsilyl-2-o-methyl-rac-glycerolAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of the protected glycerol derivative 14 (5.0 g, 16 mmol) and 10% palladium on activated carbon (wet Degussa type E101 NE/W) (0.43 g) in MeOH (50 mL) was evacuated using an aspirator pump and filled with hydrogen. After 2 h, TLC analysis showed the reaction to be complete, the mixture was filtered through Celite and the filtrate was evaporated to dryness to give 1-O-t-butyldimethylsilyl-2-O-methyl-rac-glycerol (15) (99%) as a colourless oil.

Aufarbeitung

  1. customwas evacuated
  2. additionfilled with hydrogen
  3. customthe reaction
  4. filtrationthe mixture was filtered through Celite
  5. customthe filtrate was evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-ba8d1dc08c7a47bf9954b20e010e118c
Quelldatensatz
uspto-grants-2002_04
Patentnummer
US06380177B1

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