Water → 5-(1,3-Dioxan-2-yl)-1-methyl-1H-imidazole

HRID 84358

Reaktionsgleichung

Reaktionsgleichung von HRID 84358
[CH3:1][N:2]1[C:6]([CH:7]=[O:8])=[CH:5][N:4]=[CH:3]1.[CH2:9](O)[CH2:10][CH2:11][OH:12].CC1(C)C2(CS(O)(=O)=O)C(CC1CC2)=O.O>C1(C)C=CC=CC=1.C(Cl)Cl>[O:8]1[CH2:9][CH2:10][CH2:11][O:12][CH:7]1[C:6]1[N:2]([CH3:1])[CH:3]=[N:4][CH:5]=1

Komponenten

7

Edukt 4

HCID 962WaterHCID 104421,3-PropanediolHCID 18462Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)-HCID 5735921-methyl-1H-imidazole-5-carbaldehyde

Produkt 1

HCID 579196325-(1,3-Dioxan-2-yl)-1-methyl-1H-imidazole

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1140TolueneLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 1-methyl-1H-imidazole-5-carbaldehyde (2.9 g, 26.3 mmol) in toluene (20 mL) was added propane-1,3-diol (4.01 g, 52.7 mmol) and CSA (0.306 g, 1.317 mmol) and the reaction mixture was heated to reflux with azeotropic removal of the evolved water for 24 hours. The reaction mixture was cooled to RT, diluted with DCM and washed with NaHCO3 solution.

Aufarbeitung

  1. temperaturethe reaction mixture was heated
  2. washwashed with NaHCO3 solution

Quellen und Nachweise

ORD-Eintrag
ord-e7428bd3e70b498dbb8013ec465cb6e1
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846927B2

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