Ethyl bromoacetate → Ethyl 4-(2-chloro-4-trifluoromethylphenoxy)phenoxyacetate

HRID 844918

Reaktionsgleichung

Reaktionsgleichung von HRID 844918
[Cl:1][C:2]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.Br[CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23].C(=O)([O-])[O-].[K+].[K+]>C(C(C)=O)C>[Cl:1][C:2]1[CH:15]=[C:14]([C:16]([F:18])([F:17])[F:19])[CH:13]=[CH:12][C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:9][CH:10]=1

Komponenten

5

Edukt 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 129406134-[2-Chloro-4-(trifluoromethyl)phenoxy]phenol

Produkt 1

HCID 14030465Ethyl 4-(2-chloro-4-trifluoromethylphenoxy)phenoxyacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6569Methyl Ethyl KetoneLösungsmittel

Versuchsvorschrift

1.44 parts of 4-(2-chloro-4-trifluoromethylphenoxy)phenol, 0.84 part of ethyl bromoacetate, and 1.38 parts of anhydrous potassium carbonate were refluxed for 3 hours in 20 parts by volume of methyl ethyl ketone in an atmosphere of nitrogen. After the reaction, the reaction mixture was filtered. The filtrate was concentrated, and water was added. The mixture was then extracted with ethyl acetate. The extract was washed with a 1N aqueous solution of sodium hydroxide and then with water, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give 1.5 parts of ethyl 4-(2-chloro-4-trifluoromethylphenoxy)phenoxyacetate.

Aufarbeitung

  1. customAfter the reaction
  2. filtrationthe reaction mixture was filtered
  3. concentrationThe filtrate was concentrated
  4. additionwater was added
  5. extractionThe mixture was then extracted with ethyl acetate
  6. washThe extract was washed with a 1N aqueous solution of sodium hydroxide
  7. dry with materialwith water, and dried over anhydrous sodium sulfate
  8. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e3007bbb3cd54100847a3d72bab26558
Quelldatensatz
uspto-grants-1988_07
Patentnummer
US04755209

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