Sodium Hydroxide → HCID 20130662, Verbindung

HRID 845964Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 845964
[Cl:1][C:2]1[CH:12]=[CH:11][C:10]([N:13]2[C:22](=[O:23])[C:21]3[CH2:20][CH2:19][CH2:18][CH2:17][C:16]=3[N:15]([CH3:24])[C:14]2=[O:25])=[CH:9][C:3]=1[C:4]([O:6]CC)=[O:5].[OH-].[Na+]>C(O)C.O>[Cl:1][C:2]1[CH:12]=[CH:11][C:10]([N:13]2[C:22](=[O:23])[C:21]3[CH2:20][CH2:19][CH2:18][CH2:17][C:16]=3[N:15]([CH3:24])[C:14]2=[O:25])=[CH:9][C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 20130686ethyl 2-chloro-5-[1,4,5,6,7,8-hexahydro-1-methyl-2,4-dioxo-3(2H)-quinazolinyl]-benzoate

Produkt 1

HCID 20130662HCID 20130662, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 3.6 g of ethyl 2-chloro-5-[1,4,5,6,7,8-hexahydro-1-methyl-2,4-dioxo-3(2H)-quinazolinyl]-benzoate in 70 ml of ethanol is held at 60° C. for 10 minutes with 0.6 g of sodium hydroxide in 70 ml of water and subsequently stirred for 1 hour. The solution is substantially evaporated down under reduced pressure and the residue is brought to pH 1 with 2N hydrochloric acid. The precipatate is shaken five times with 50 ml amounts of diethyl ether and the organic phases are dried over anhydrous sodium sulphate and evaporated to dryness under reduced pressure. 2-Chloro-5-[1,4,5,6,7,8-hexahydro-1-methyl-2,4-dioxo-3(2H)-quinazolinyl]-benzoic acid is obtained.

Aufarbeitung

  1. customThe solution is substantially evaporated down under reduced pressure
  2. stirringThe precipatate is shaken five times with 50 ml amounts of diethyl ether
  3. dry with materialthe organic phases are dried over anhydrous sodium sulphate
  4. customevaporated to dryness under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-25b81acac29443d7aeee167816b3c817
Quelldatensatz
uspto-grants-1988_07
Patentnummer
US04760163

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