2-(2-Benzoyloxypropan-1-yl)-3-octadecylcarbamoyloxypropylamine → 2-(2-Benzoyloxypropan-1-yl)-3-hexadecylthiopropylamine

HRID 847020Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 847020
[N:1]([CH2:4][CH:5]([CH2:24][CH:25]([O:27][C:28](=[O:35])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH3:26])[CH2:6][S:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[N+]=[N-].C(OC(C)CC(COC(=O)NCCCCCCCCCCCCCCCCCC)CN)(=O)C1C=CC=CC=1>[Pd].CO>[C:28]([O:27][CH:25]([CH3:26])[CH2:24][CH:5]([CH2:6][S:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:4][NH2:1])(=[O:35])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Komponenten

5

Edukt 2

HCID 148350122-(2-Benzoyloxypropan-1-yl)-3-octadecylcarbamoyloxypropylamineHCID 198841951-Azido-2-(2-benzoyloxypropan-1-yl)-3-hexadecylthiopropane

Produkt 1

HCID 148350152-(2-Benzoyloxypropan-1-yl)-3-hexadecylthiopropylamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture is 1.291 g (2.56 mM) of 1-azido-2-(2-benzoyloxypropan-1-yl)-3-n-hexadecylthiopropane m12b, 130 mg of 10% palladium on charcoal in 130 ml of methanol is hydrogenated by the same procedure as described in (129) and crude product of the titled compound m13 is obtained.

Quellen und Nachweise

ORD-Eintrag
ord-009f987007b5436c9d88830f80a46847
Quelldatensatz
uspto-grants-1992_08
Patentnummer
US05138067

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