Methyl Acrylate → 4-Morpholinepropanoic acid, methyl ester

HRID 847636

Reaktionsgleichung

Reaktionsgleichung von HRID 847636
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:7]([O:11][CH3:12])(=[O:10])[CH:8]=[CH2:9]>ClCCl>[N:1]1([CH2:9][CH2:8][C:7]([O:11][CH3:12])=[O:10])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 7294Methyl AcrylateHCID 8083Morpholine

Produkt 1

HCID 1013734-Morpholinepropanoic acid, methyl esterAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 4.9 ml (56 mmol) of morpholine in 50 ml of dichloromethane was treated dropwise with 5.0 ml (56 mmol) of methyl acrylate. The resulting solution was allowed to stand at ambient temperature for 3 days, after which it was concentrated in vacuo to an oil. Chromatography on silica gel using 0.5% methanol/2% isopropylamine in chloroform provided 9.54 g (99%) of the desired compound as a colorless liquid.

Aufarbeitung

  1. concentrationafter which it was concentrated in vacuo to an oil

Quellen und Nachweise

ORD-Eintrag
ord-8edfa088586d458692cabaee57cf64fa
Quelldatensatz
uspto-grants-1992_08
Patentnummer
US05142056

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