2-Chlorobenzamide → 1-(2-Chlorobenzoyl)-3-(5-trifluoromethyl-2-pyrazinyl)urea

HRID 847712

Reaktionsgleichung

Reaktionsgleichung von HRID 847712
N1C=CN=CC=1N=C=O.[Cl:10][C:11]1[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=1[C:13]([NH2:15])=[O:14].[F:20][C:21]([F:32])([F:31])[C:22]1[N:23]=[CH:24][C:25]([N:28]=[C:29]=[O:30])=[N:26][CH:27]=1>>[Cl:10][C:11]1[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=1[C:13]([NH:15][C:29]([NH:28][C:25]1[CH:24]=[N:23][C:22]([C:21]([F:32])([F:20])[F:31])=[CH:27][N:26]=1)=[O:30])=[O:14]

Komponenten

4

Edukt 3

HCID 691112-ChlorobenzamideHCID 189876442-IsocyanatopyrazineHCID 20567021Pyrazine, 2-isocyanato-5-(trifluoromethyl)-

Produkt 1

HCID 133410811-(2-Chlorobenzoyl)-3-(5-trifluoromethyl-2-pyrazinyl)urea

Versuchsvorschrift

A compound of formula I may also be prepared by allowing a 2-substituted benzamide to react with a 2-pyrazinylisocyanate utilizing the appropriate solvents, times of reaction and general reaction conditions hereinabove described. For example, 2-chlorobenzamide is allowed to react with 5-trifluoromethylpyrazin-2-ylisocyanate to yield 1-(2-chlorobenzoyl)-3-(5-trifluoromethyl-2-pyrazinyl)urea, having a melting point of about 219°-220° C.

Aufarbeitung

  1. customA compound of formula I may also be prepared
  2. customthe appropriate solvents, times of reaction and general reaction conditions

Quellen und Nachweise

ORD-Eintrag
ord-201e548ca6654fdda4946ea34b17dce2
Quelldatensatz
uspto-grants-1981_10
Patentnummer
US04293552

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