Methanol → 4-Chloro-2-methoxybenzothiazole
Reaktionsgleichung
Br[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:5]=2[N:6]=1.[OH-:12].[Na+].[CH3:14]O>O>[CH3:14][O:12][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:5]=2[N:6]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
2-Bromo-4-chlorobenzothiazole (6.21 g, 0.025 mole) and 94% sodium hydroxide (1.57 g, 0.037 mole) were added to methanol (100 c.c.), and the mixture was heated under reflux for 30 minutes. After cooling, water (100 c.c.) was added to the reaction solution, followed by ice-cooling. The deposited crystals were filtered and washed with water to obtain 4.68 g of 2-methoxy-4-chlorobenzothiazole. Yield 93.8%, purity 99.3%, m.p. 55°-57° C.
Aufarbeitung
- temperaturethe mixture was heated
- temperatureunder reflux for 30 minutes
- temperatureAfter cooling
- temperaturecooling
- filtrationThe deposited crystals were filtered
- washwashed with water
Quellen und Nachweise
- ORD-Eintrag
- ord-6e26b00862f84353ab12bbfba02506a2
- Quelldatensatz
- uspto-grants-1981_10
- Patentnummer
- US04293702
Notizen zur Reaktion
Wird geladen…