Sodium Hydroxide → 4-Chloro-2-methoxybenzothiazole

HRID 847796

Reaktionsgleichung

Reaktionsgleichung von HRID 847796
Cl[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:5]=2[N:6]=1.[OH-:12].[Na+].O.[CH3:15]O>O>[CH3:15][O:12][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:5]=2[N:6]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 771772,4-DichlorobenzothiazoleHCID 22242641Methanol--water (1/1)

Produkt 1

HCID 41419694-Chloro-2-methoxybenzothiazoleAusbeute 92,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

2,4-Dichlorobenzothiazole (10.21 g, 0.05 mole) and 94% sodium hydroxide (8.30 g, 0.075 mole) were added to a 50 (V/V) % water/methanol mixed solvent (150 c.c.), and the mixture was heated under reflux for 30 minutes. After cooling, water (100 c.c.) was added to the reaction solution, followed by ice-cooling. The deposited crystals were filtered and washed with water to obtain 9.22 g of 2-methoxy-4-chlorobenzothiazole. Yield 92.4%, purity 100%, m.p. 55°-57° C.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 30 minutes
  3. temperatureAfter cooling
  4. temperaturecooling
  5. filtrationThe deposited crystals were filtered
  6. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-1378ba8683e34588b66f6a2080ac745c
Quelldatensatz
uspto-grants-1981_10
Patentnummer
US04293702

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