Water → 2-n-Propoxy-4-chlorobenzothiazole

HRID 847799

Reaktionsgleichung

Reaktionsgleichung von HRID 847799
Br[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:5]=2[N:6]=1.ClC1S[C:15]2[CH:21]=CC=C(Cl)[C:16]=2N=1.[OH-:23].[Na+].O>C(O)CC>[CH2:21]([O:23][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:5]=2[N:6]=1)[CH2:15][CH3:16]

Komponenten

6

Edukt 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 771772,4-DichlorobenzothiazoleHCID 771782-Bromo-4-chlorobenzothiazole

Produkt 1

HCID 127660072-n-Propoxy-4-chlorobenzothiazoleAusbeute 97,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 10311-PropanolLösungsmittel

Versuchsvorschrift

A mixture (11.30 g, 0.05 mole) of 2-bromo-4-chlorobenzothiazole and 2,4-dichlorobenzothiazole and 94% sodium hydroxide (2.34 g, 0.055 mole) in n-propanol (100 c.c.) was heated under reflux for 1 hour. Water was added and the alcohol was distilled azeotropically together with water. The resulting oily substance was extracted with chloroform, and the chloroform layer was washed with water. The solvent was removed under reduced pressure to obtain 11.12 g of 2-n-propoxy-4-chlorobenzothiazole as a yellow viscous liquid. Yield 97.7%, purity 98.9%, b.p. 106°-108° C./0.12 mmHg.

Aufarbeitung

  1. temperatureunder reflux for 1 hour
  2. distillationthe alcohol was distilled azeotropically together with water
  3. extractionThe resulting oily substance was extracted with chloroform
  4. washthe chloroform layer was washed with water
  5. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-705986d35b744ee8a86accc645a337d5
Quelldatensatz
uspto-grants-1981_10
Patentnummer
US04293702

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