Dimethyl Sulfoxide → HCID 12774893, Verbindung

HRID 848637Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 848637
Cl[CH:2]1[CH2:6][CH2:5][O:4][CH:3]1[N:7]1[C:12](=[O:13])[NH:11][C:10](=[O:14])[CH:9]=[N:8]1.CC(C)([O-])C.[K+].CS(C)=O>C(O)(=O)C>[O:4]1[CH2:5][CH:6]=[CH:2][CH:3]1[N:7]1[C:12](=[O:13])[NH:11][C:10](=[O:14])[CH:9]=[N:8]1

Komponenten

5

Edukt 3

HCID 679Dimethyl SulfoxideHCID 127749012-(3-Chlorooxolan-2-yl)-1,2,4-triazine-3,5(2H,4H)-dioneHCID 23665647Potassium tert-butoxide

Produkt 1

HCID 12774893HCID 12774893, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

2-(3-Chloro-tetrahydro-2-furanyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine (0.8 g) and potassium t-butoxide (0.7 g) are added to dimethyl sulfoxide (3 ml), and the mixture is stirred at room temperature for 3 hours. The reaction mixture is poured into ice-water. The mixture is acidified with acetic acid and extracted with chloroform. The chloroform extract is washed with water, dried and evaporated to remove the solvent. The crude residue is recrystallized from ethanol to give 2-(2,5-dihydro-2-furanyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine (Compound No. 81). Yield, 0.5 g (76%). M.P., 147°-148° C.

Aufarbeitung

  1. extractionextracted with chloroform
  2. extractionThe chloroform extract
  3. washis washed with water
  4. customdried
  5. customevaporated
  6. customto remove the solvent
  7. customThe crude residue is recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-aed1f257c4e94e90b2af6397342a3b5f
Quelldatensatz
uspto-grants-1981_10
Patentnummer
US04297129

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