6-Benzylpyridin-2-amine → HCID 178507544, Verbindung

HRID 849158

Reaktionsgleichung

Reaktionsgleichung von HRID 849158
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1>C(O)(=O)C.[Rh]>[NH:1]=[C:2]1[CH2:7][CH2:6][CH2:5][CH:4]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[NH:3]1

Komponenten

4

Edukt 1

HCID 939026-Benzylpyridin-2-amine

Produkt 1

HCID 178507544HCID 178507544, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23948RhodiumKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Example 298) A sample of the 2-amino-6-benzylpyridine product of Example 298 A was reduced in acetic acid under hydrogen atmosphere utilizing 5% Rh/C catalyst to afford 2-imino-6-benzylpiperidine as an oil. The oil was purified by C-18 reverse phase chromatography to give a white solid. The solid was dissolved in 1N HCl, lyophilized, and recrystallized from EtOH/EtOAc to give the title product as a white solid.

Quellen und Nachweise

ORD-Eintrag
ord-f969f49f24934845b7a38b501b51d7de
Quelldatensatz
uspto-grants-2000_01
Patentnummer
US06011028

Verknüpfte Notizen

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