3-Amino-1-propanol → HCID 19369791, Verbindung
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:21]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:22][C:23]([F:26])([F:25])[F:24])[C:15]=3[N:14]=[C:13](Cl)[C:12]=2[CH2:11][CH2:10]1.[NH2:28][CH2:29][CH2:30][CH2:31][OH:32]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:21]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:22][C:23]([F:26])([F:25])[F:24])[C:15]=3[N:14]=[C:13]([NH:28][CH2:29][CH2:30][CH2:31][OH:32])[C:12]=2[CH2:11][CH2:10]1Komponenten
3
Versuchsvorschrift
1-(2-Methoxyphenyl)-4-chloro-6-trifluoromethoxy-2,3-dihydropyrrolo[3,2-c]quinoline(600 mg, 1.5 mmol) was dissolved in 3-amino-1-propanol(6 ml) in the pressure tube, and reacted at the same condition of Step 3 in the Example 12 to obtain 570 mg of desired compound as solid in 88% of yield.
Aufarbeitung
- customreacted at the same condition of Step 3 in the Example 12
Quellen und Nachweise
- ORD-Eintrag
- ord-29457af8d9964bf9943363833917de2a
- Quelldatensatz
- uspto-grants-2000_01